Powder Oral Water Soluble Drugs - 1036 Words

About 70% of the new chemcial ntities are recognized as poorly water-soluble about 40% of commercially available immediate-release oral formulations are recognized as practically insoluble in water (Kawabata et al., 2001). Therefore, several potentially promising drug candidtates were rejected as pharmaceutical products due to ther poor solubilitty in GI fluid, poor dissolution in GI tract, low systemic absorption and thus poor oral bioavailability (therapeutically ineffective) (Hà ¶rter and Dressman, 2001). Therefore, enhancing the aqueous solubility and dissolution rate of poorly water-soluble drugs is one of the major challenges in pharmaceutical industry. The study was performed to improve the compactibility and the biopharmaceutical performance of xylitol by improving its physicomechanical properties to make it better suited for tableting using direct compression. To this end, antisolvent crystallization technique was employed in the presence of various additives, i.e., polyethylene glycol (PEG), polyvinylpyrrolidone (PVP) and polyvinyl alcohol with a molecular weight (PVA22000) or 16000 (PVA16000) at varying concentrations (0.06%, 0.3%, 0.6% and 1.2%, w/v). The size and morphological changes induced by crystallization the in presence of the additives were studied. The dissolution performance of crystallized xylitols formulated with a model poorly water-soluble drug, i.e. indomethacin, in comparison to commercial xylitol were also evaluated. Materials and MethodsShow MoreRelatedEssential Drug Delivery Route Is No Doubt The Oral Route1408 Words   |  6 Pages The most essential drug delivery route is no doubt the oral route. It has advantages like convenience of administration and less developed cost. Drugs administered by oral route are solid oral dosage forms particularly tablets, the preferred class of product. Today drug delivery companies are concentrating on solid oral drug delivery systems that suggestion increased patient amenability and effect. Melt in mouth tablet (MMT)Read MoreTherapeutic Response Of A Drug Depends Upon The Dissolution Rate Of Water Insoluble Drugs Essay2676 Words   |  11 PagesTherapeutic response of a drug depends upon the bioavailability which in turn depends upon the solubility and dissolution rate of drug. A solubility problem is a major challenge for the pharmaceutical industry with developments of new pharmaceutical products. There are various techniques but liquisolid compact is a new and promising method that can change the dissolution rate of water insoluble drugs. According to the concept of liqui solid systems water-insoluble drugs dissolved in suitable non-volatileRead MoreVirtual Pharmaceutical: How It Works2390 Words   |  10 PagesOur company name: Virtual Pharmaceutical Drug name: VPL874C (Market name = Betatrix) Possible indications = migraine prophylaxis, hypertension, coronary heart disease Problem – want oral dosage form. - but has short half life (3-4hr) Solution – oral dosage form with extended release which releases drug slowly so that the plasma concentrations are maintained at a therapeutic level for a prolonged period of time (usually between 8 and 12 hours). Recent extended release formulationsRead MoreThe Human Gastrointestinal Track Is A Complex Time9513 Words   |  39 Pagesmetabolizing, and excretive organ. 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Though AED therapy is meant for a long duration usage , because of this , there is a risk of drug interactions and this problem is further compounded by the high protein bindings for some drugs and potentialRead MoreHow Riluzole Is A Derivative Of Benzothiazole Essay724 Words   |  3 Pagesto slight yellow powder soluble in dimethylsulfoxide, dimethylformamide and methanol, freely soluble in dichloromethane, sparingly soluble in 0.1 N HCl and very slightly soluble in water and 0.1 N NaOH. Riluzole is available as a capsule-shaped, white, film-coated tablet for oral administration. Each tablet contains 50 mg of riluzole. It is marketed by Sanofi-Aventis with the brand name Rilutek. 2.11.3 Side-effects or damaging effects Riluzole is a very good neuroprotective drug, but it has someRead MorePowder X: Ray Diffraction1726 Words   |  7 PagesPowder X–Ray Diffraction Powder X–ray diffraction (PXRD) was used to provide an insight into the polymorphic nature of xylitols. The PXRD patterns of all xylitols were collected on a Bruker D8 Advance (Siemens, D5000, Germany) powder diffractometer with Cu KÃŽ ± radiation (1.54056 Ã…) using the DIFFRACplus software. Samples were placed into a stainless steel holder and the surface of each powder was levelled manually for analysis. Each sample was scanned from 2 to 40 of 2ÃŽ ¸ with a step size of 0.019 ºRead MoreDrug Profile : Drugs And Drugs1406 Words   |  6 PagesLevel 1: Drug Profile Coursework Drug substance: Pioglitazone Name: Cheong Hung Shing Student number: 40168923 Assessor: Dr P. McCague â€Æ' ï  ¬ 1.1 Source Pioglitazone is one kind of thiazolidinediones which is a type of anti-diabetic drugs. It is a synthetic substance. It has brand names of Actos ®. [1][2] ï  ¬ 1.2 Description Pioglitazone is 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione. 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Architecture Of The 20th Century Architecture Essay Free Essays

string(71) " blurred the boundary lines between kitsch and high art yet once more\." While discoursing the topic of architecture of the twentieth century, the treatment is uncomplete without a particular reference of Robert Venturi. The adult male started his life in Philadelphia on 25th June, 1925 he went on to go one of the most prevailing names in American architecture. The information on Venturi includes a particular reference of his married woman Denise Scott Brown. We will write a custom essay sample on Architecture Of The 20th Century Architecture Essay or any similar topic only for you Order Now 1960 was the twelvemonth they foremost meet, got married in 1967 they have ever been together of all time since. This hubby and married woman squad did singular work in the part of architecture, establishing themselves with their joint venture better recognized as Venturi, Scott Brown A ; Associates ( VSBA ) . â€Å" Architecture steeped in popular symbolism. Kitsch had become art in designs which exaggerate or stylise cultural icons. † [ 1 ] Some of the most of import design schemes adopted by Brown were ‘theory is non the regulation of pollex ‘ , ‘learn to copy ‘ , ‘drawing-a must hold ‘ , ‘ideation is changeless ‘ etc. Harmonizing to Robert and Denise, theory is non the regulation of pollex. While most designers glued to theory when it comes to be aftering designs, Robert Venturi and Denise Scotte Brown thought the opposite manner. Harmonizing to them plan procedure should non be dominated by the theory. This was despite the fact that both of them were good known theorists. Venturi even went on to state that â€Å" the creative person is non person who designs in order to turn out his or her theory and surely non to accommodate an political orientation † [ 2 ] While most of the designers followed the doctrine of non copying, Venturi and Brown had a different point of position here excessively. They believed that they could larn more by copying the plants of the Masterss. As Venturi right puts Forth, â€Å" It is better to be good than to be original. † [ 3 ] But, this in no manner meant a complete imitation. To this, Denise Scott Brown makes it clear that they copy ideology that they copy political orientations. The couple merely took copying to the extent of pulling inspiration. Their inspiration was a base to develop farther designs. Venturi says, â€Å" You have to hold something basic that you either construct on or germinate from or revolt against. You have to hold something at that place in the first topographic point and the lone manner to acquire it is to copy, in a good sense of the word. â€Å" [ 3 ] One, of co urse, needs to possess certain accomplishments to go forth a grade the field of architecture. Harmonizing to Robert and Denise, pulling was the most indispensable 1. Mentioning to the accomplishment as a installation between manus and head, Denise Scott Brown besides said that it was indispensable for interior decorators to get the hang pulling in order to win. She believed that it frequently happened that the manus draws something, which the head interprets in a different manner and you draw a whole new thought from it. In an epoch where everyone thought that script has a small significance as everything can be done utilizing specially designed package, the couple has its statements ready. â€Å" Peoples who can pull really good and who control line weight good in manus technique are the 1s who use the computing machine imaginatively, † [ 4 ] they asserted. Who says that you need to sit down in a board room to imagine? Well, non Venturi at least. In his sentiment ideation can non be bound by topographic point or clip ; he believed that one could imagine anytime and anyplace, even while speaking. Venturi alleged â€Å" that even while speaking one all of a sudden sees something else out of the corner of their oculus and they think of something they would n’t hold done otherwise. He besides opined that you ideate more while working on other undertakings and averred the thought merely comes after great battle and torment. â€Å" [ 5 ] Some of the of import edifices built by the couple are – The Vanna Venturi House, Chestnut Hill, Philadelphia, Pennsylvania in 1962, Brant House in Greenwich, Connecticut in 1973, Gordon Wu Hall in Princeton, New Jersey in 1983, Bank edifice in Celebration in Florida in 1994 and many more. Since mid 1960s Robert and Denise greatly altered the landscape of the American Architectural thought their procedures and patterns with their design schemes. Robert Venturi ‘s book ‘Complexity and Contradiction in ArchitectureA became a uniting point for budding designers around the Earth who had become misanthropic with the stylistic limitations of the International Style as a consequence of which the book provided a pronunciamento for the Post-Modern motion in architecture. Followed by this out of his instructions at Yale came his 1972 bookA Learning from Las Vegas which was A co-authored by Steven Izenour and Denise Scott Brown. The architectural universe was one time once more astonished by this work. The the gaudy and the sign-filled Vegas strip was transformed from being an architectural aberrance to a common art signifier which deserve serious survey. Venturi felt that the Decorated Shed and assorted other types of wayside edifices offered design lessons that coul d non be left accompanied, an † he argued that designers require to confront the world and typify the popularly built environment with edifices matching to that environment. â€Å" [ 6 ] â€Å" KitschA is reflected as a signifier of art that is deficient and is a tastelessA transcript of an a complementary manner of art or is a nugatory reproduction of art of recognized value. â€Å" [ 7 ] A The deliberate usage of elements that may be considered asA cultural icons is what this construct is related to â€Å" KitschA can besides be defined as the genres of art that aesthetically lack whether or non being theatrical, sentimental, glamourous, or originative and that make originative gestures which merely reflect the superficial visual aspects of art by agencies of perennial conventions and expression. This term is frequently associated with excessiveA mawkishness. † [ 8 ] The outgrowth ofA postmodernismA in the 1980s, blurred the boundary lines between kitsch and high art yet once more. You read "Architecture Of The 20th Century Architecture Essay" in category "Essay examples" The blessing of what is called campA gustatory sensation – which may be related to, but is non the same as cantonment when used as a homosexual esthesia was one development. An unreal or an false illustration from the universe of painting would be a kitsch image of a cervid by a lake. In doing cantonment, puffing a mark beside it, stating No Swimming. The olympian or romantic perceptual experience of a baronial animate being would be punctured by wit ; the construct of an carnal having a a punishment for the breach of the regulation is out justly farcical. The aboriginal, brooding mawkishness of the motive is neutralized, and therefore, it becomes cantonment. A few things that posed as interesting challenges were the conceptual artA and deconstruction, because, speaking of kitsch, in favor of elements that enter it by associating to other domains of life they downplayed the formal construction of the graphics. Inspite of this fact, many in the art universe continue to latch onto some sense of the duality between art and kitsch, excepting all sentimental andA realisticA art from being considered earnestly. This has come under the scanner of the critics, who now argue for a renewed art and nonliteral picture, without the concern for it looking advanced or new. Whatever may be the scenario, there is trouble in specifying boundaries between kitsch and all right art since the beginning of postmodernism, the word kitsch is normally used to label anything seen as being in hapless gustatory sensation still. This postmodern architecture influenced by Venturi was further prejudiced by many designers like Philip Johnson and Robert A.M Stern. When speaking about American architecture, there is no manner one can lose out on Philip Johnson. One of the most noteworthy and celebrated American designers, he was the victor of the first ‘Pritzker Architecture Prize ‘ . For set uping the Department of Architecture and Design at the Museum of Modern Art, New York is credited to him. Philip was born in 1906 in Cleveland. He played a critical function in making and understanding the urban skyscrapers through America. Johnson was an advocator of simple manner and therefore he played a important function in beef uping the minimalist tendency. The work of assorted modern designers, including Mies van der Rohe, Walter Gropius and Le Corbusier was comprehensively supported by Johnson. He was a co-author of the popular book, ‘The International Style ‘ . The techniques of the Bauhaus were introduced to America by this book. By the clip Johnson reached the age of thirtiess he was discontented with his function of an writer and conservator. So he studied under the designer Marcel Breuer at The Graduate School of Design. Johnson designed his ain place in New Canaan, Connecticut shortly after his graduation. His first architectural work, his house is considered one of his most singular plants. The house was a glass house and featured an exposed steel frame. Johnson continued with his architectural pursuit and went on to plan legion public edifices and houses after his ain house. Johnson designed some of his well-known plants, notably the Seagram Building in New York City during this clip. Johnson had a more divine than individualistic stretch with architecture ab initio. His initial work carried a strong bear grade of Mies van der Rohe. However, an individualistic touch could be seen in his work by 1960 ‘s. Infused with historical elements, his manner of architecture showcased how one could aesthetically integrate domes and colonnades in a edifice. He created some of his most monumental plants of his life merely after he discovered his individualistic architectural sense. Some of these include the Sheldon Art Gallery at the University of Nebraska, the New York State Pavilion at the World ‘s Fair and the New York State Theater in New York City. By the 1970s and 1980s, he began experimenting with the texture and colour of the outside of his creative activities at big though he was still stuck with his original manner of architecture. Today in his 1890ss, Johnson is considered as one of the last modern designers that we have. With a tally of about 70 old ages in the field of architecture, he has certainly carved his niche and will go on to animate many designers in the times to come. Another popular name in American architecture is of Robert Arthur Morton Stern, besides known as Robert A.M. Stern. He is an American designer and soon the Dean of Yale University School of Architecture. His work is normally described as postmodern. However, a ruling accent on continuity of tradition in his work is witnessed which can non be ruled out. No admiration, he late used the phrase ‘modern diehard ‘ to depict his work. As a interior decorator in the office of Richard Meier he started his calling in 1966. But he shortly quit from his occupation and established his ain house, ‘Stern and Hagmann ‘ in 1969. He formed the house with a fellow pupil at the Yale University named John S. Hagmann. This was followed by the constitution of the replacement house, ‘Robert A.M. Stern Architects ‘ , a name still really popular in American architecture. He has a wide portfolio to his recognition when speaking about his work. Some of his more noteworthy undertakings in the public sphere include Lakewood Public Library in Lakewood, Ohio, the chief library in Columbus, Federal Reserve Bank in Atlanta and many more. Stern was besides a noteworthy writer apart from being a successful designer. He has authored New York 1880, New York 1960, and New York 2000- a series that paperss the development and history of the architecture of New York City. This postmodern architecture has his roots deep in the past, as is apparent from his work. His edifices showcase a deep fondness for the yesteryear. His most noteworthy undertaking with The Walt Disney Company reiterates the same. He served the company in the place of Board of Director for the term of office 1992-2003. His boardwalk at Disney World is implicative of an American seaboard small town from the early twentieth century. You will be reminded of how architecture has evolved from Victorian to the Vienna Secessionist motion while you have a expression at his edifices. The mini small town beautified with artefacts from assorted epochs, though non precisely historical, comes across as a dream like walk. And non to bury the Beach nine, that reflects the nineteenth century American Resort architecture in its true signifier. With a immense pool of work and a design doctrine that combined the best of modernism and tradition, Stern is surely non a name to be forgotten in the architectural kingdom. Though his wide skyline of work is a effort in itself, he has several other accomplishments to his recognition every bit good. A Driehaus Prize laureate, he went on to win several awards. In the twelvemonth 1984, he was awarded with the AIA New York Chapter ‘s Medal of Honor. He was besides conferred the Chapter ‘s President ‘s Award in 2001.A He besides has to his recognition the Scully Prize from the National Building Museum, Athena Award from the Congress for the New Urbanism and the Board of Directors ‘ Honor from the Institute of Classical Architecture and Classical America. â€Å" Since long and even now Philip ‘s designs in PoMo manner reveal a decent to the degree of kitsch that appears lest cantonment in its motive than merely and unmitigately inexpensive in its consequence † [ 9 ] . In the aesthetic plan of Robert Venturi kitsch and the country of mundane civilization was used. But at the same clip in his artistic designs, he by and large elevated them. In the circle of designers â€Å" Robert Venturi an Robert A M Stern, the so called Greys Designers whose work used the intercrossed civilization parlances of American twenty-four hours to twenty-four hours life as get downing points of their new artistic way including kitsch and dad. † [ 10 ] Thus Robert Venturi, Philip and Robert A M Stern are three showy modern designers whose part to architecture hold a made a difference to the architectural universe. How to cite Architecture Of The 20th Century Architecture Essay, Essay examples

Are Americans Allergic to Traveling Abroad Essay Example For Students

Are Americans Allergic to Traveling Abroad? Essay Are Americans Allergic to Traveling Abroad? Essay I asked Poonam, an immigrant from Nepal, who states that such a notion is ridiculous. Nepal has suffered lately due to a despotic ruler. The newspapers have recently reported that the king has cut off Nepal from the rest of the world by closing airports and shutting down communication. Poonams father owns a resort in Nepal, and his family has struggled to keep business open through these tough times. How do you explain that only 15% of Americans have passports to travel abroad? Is it because we are lazy? Poonam furthers that Americans are not lazy or allergic to traveling. He points out that Americans do not have the time to travel abroad. The strength of our economy is based on the working class. He points out that most employees only receive one to two weeks of vacation. In Nepal if he were to take a vacation, his employer would give him one to two months off so that he can travel and enjoy himself. He explains that to travel to Nepal, it takes two days to get there and two takes to get back home (Baltimore). The weary traveler usually needs a day or two after each way to recover from any jet lag or from the pure exhaustion of balancing airplane and other time schedules. Poonam also points out, the vast land in United States allows Americans the opportunity to take mini-trips that can be very enriching. This is one of his favorite aspects of our country. Poonam who works 72 hour work weeks without overtime, will spend his only day off taking his son and wife to Washington D.C. or Philadelphia. We both agree that this point is overlooked. Traveling abroad is reserved for those who do not have to work the independently wealthy. Poonam does not believe that apathy prevents us from travel, but rather our drive to succeed in our careers. I posed the question as to whether or not we work too much? He reminds me of the French government who require mandatory vacations and 35 hours work weeks. I counter with a recent news article that reported a decline in the French economy. The French government is thinking of reversing the 35 hour work week law. I am definitely very interested in traveling. I have started taking French lessons so that I can travel abroad. I would love to be able to work in the international realm of healthcare or political relations. I have just filled out the paperwork for my passport. I have to go get my picture taken and then I will be ready to submit my application. My goal is to spend a whole semester abroad during my tenure here at UMBC; although, I would also like to spend some time during the summer volunteering in Indonesia. My pen pal who lives in Southern France states that Americans should not waste time learning another language, for she believes that I should spend more time furthering myself in the sciences. I believe that we should show respect when visiting other countries though. Out of respect, we should try to learn some of their cultures which includes at least learning greetings and other conversational customs. .